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FLASH GENE
Symbol ASCC1 contributors: mct - updated : 16-03-2016
HGNC name activating signal cointegrator 1 complex subunit 1
HGNC id 24268
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA-binding KH domain fused to a 2H RNA-phosphoesterase
    • HOMOLOGY
    interspecies ortholog to murine Ascc1
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • enhancing NF-kappa-B, SRF and AP1 transactivation
  • TRIP4 and ASCC1 are indispensable for motor system development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of TRIP4 complex containing ASCC1, ASCC2 and ASCC3, the activating signal cointegrator 1 (ASC-1) complex
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCSMA3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS