Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TPRKB contributors: mct - updated : 25-09-2019
HGNC name TP53RK binding protein
HGNC id 24259
Corresponding disease
GAMOS5 Galloway-Mowat syndrome 5
Location 2p13.1      Physical location : 73.956.956 - 73.964.517
Synonym name
  • PRPK (p53-related protein kinase)-binding protein
  • CGI-121 protein
  • TPRKB protein
  • Synonym symbol(s) CGI-121, CGI121, GAMOS5
    DNA
    TYPE functioning gene
    STRUCTURE 7.57 kb     5 Exon(s)
    text structure exon 1 is non coding
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 752 19 175 - 2003 12659830
    5 splicing 659 16.1 142 - 2003 12659830
    also called variant L1
    6 splicing 842 - 175 - 2003 12659830
    also called variant S1
    5 - 758 - 175 - 2003 12659830
    6 - 875 23 214 - 2003 12659830
    5 - 662 16.1 142 - 2003 12659830
    6 - 878 23 214 - 2003 12659830
    6 - 882 - 157 - 2003 12659830
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivemale systemtestis  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Tprkb
    Homologene
    FAMILY
  • CGI121/TPRKB family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acting as a potent inhibitor of the binding of TP53RK to p53 (Miyoshi 2003)
  • unique and specific requirement of TPRKB in a variety of TP53-deficient cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    protein catabolism
    a component
  • member of the tRNA-modifying EKC/KEOPS complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRPK
  • OSGEP is regulated at two levels by the primordial protein kinase TP53RK, which is itself regulated by TPRKB
  • cell & other
    REGULATION
    induced by phosphorylation of p53 at Ser 15 (Miyoshi 2003)
    ASSOCIATED DISORDERS
    corresponding disease(s) GAMOS5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS