Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NEUROG2 contributors: mct/npt - updated : 12-07-2018
HGNC name neurogenin 2
HGNC id 13805
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a HLH domain
  • a ser-rich domain
    • HOMOLOGY
    interspecies homolog to murine Neurog2
    homolog to rattus LOC295475
    Homologene
    FAMILY neurogenin subfamily of bHLH transcription factor
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in neurogenesis from migratory neural crest cells
  • proneural basic helix-loop-helix (bHLH) transcription factors not only initiating neuronal differentiation but also potentiating cell migration
  • controls neurogenesis in the embryonic cerebral cortex
  • induces RND2 expression directly or indirectly by a transcriptional cascade, in the embryonic cortex by directly interacting with an enhancer located 3' to the gene
  • unique role in dentate gyrus neurogenesis during development and raise the possibility that NEUROG2 has a similar function in adult neurogenesis
  • critical role of for NEUROG2 and NEUROD1 in controlling neuronal commitment and hippocampal granule neuroblast formation, both during embryonic development and in post-natal hippocampal granule neurogenesis
  • transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons
  • NEUROG2 and ASCL1 regulate the temporal progression of retinal neurogenesis by directing overlapping waves of neuron formation
  • acts as a master regulator of neuronal differentiation
  • is essential for neuronal commitment, cell cycle withdrawal, and neuronal differentiation
  • drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle
  • during central nervous system development, NEUROG2 contributes to many distinct neuronal types by specifying their fate and/or dictating development of their morphological features
  • represents a key regulator of Purkinje cells (PCs) development and maturation
  • NEUROG2 simultaneously activates and represses alternative gene expression programs in the developing neocortex
  • NEUROG1/NEUROG2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium
  • NEUROG1 and NEUROG2 control two waves of neuronal differentiation in the piriform cortex
  • enhances the neuronal differentiation of skin-derived precursors
  • APP-stimulated neuronal differentiation of neural stem/progenitor cells (NSPCs) is mediated by NEUROG2
  • proneural gene that directs neuronal differentiation of progenitor cells during development, and can enhance the generation of patient-specific induced neuronal cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • likely phosphorylated OLIG2 proteins form stable homodimers, whereas unphosphorylated OLIG2 prefers to form heterodimers with other bHLH proteins such as NEUROG2
    • INTERACTION
    DNA binding, requires dimerization with another bHLH protein
    RNA
    small molecule
    protein
  • interactions with OLIG2, to modulate gene expression in motor neuron progenitor cells
  • targeting MYT1, NHLH1, EBF3, EBF2, HES6, CBFA2T2, NEUROD1, NEUROD4 (bind these enhancers to activate targets that execute core programs regulating neurogenesis)
  • NEUROD4 is a dorsally restricted NEUROG2 transcriptional target and cofactor, which synergizes with NEUROG2 to accelerate target gene transcription in the cortex
  • CBFA2T2 physically interacts with NEUROG2 and represses transcriptional activity of NEUROG2 (proper termination of NEUROG2 activity by CBFA2T2 is necessary for normal progression of neurogenesis in the developing spinal cord)
  • LMO4 functions as a novel co-factor of NEUROG2 in the developing cortex
  • interacting with PAX3 (PAX3 plays a role in regulating HES1 and NEUROG2 activity and thereby stem cell maintenance and neurogenesis)
  • NEUROG2 is a direct upstream activator of ZBTB18 expression
  • ZBTB18 represses NEUROG2 transcription to regulate the NEUROG2-RND2 pathway
  • DMRT3, induced NEUROG2 expression in the dorsal telencephalon
  • overexpression of DMRTA1 induced the expression of the proneural gene Neurogenin2 (NEUROG2) and conversely repressed ASCL1, a proneural gene expressed in the ventral telencephalon
  • NEUROG2, NEUROD1, and EBF3 inducing MTURN
  • critical role for CEND1 in NEUROG2-driven astrocytic reprogramming
  • WNT signaling suppresses oligodendrogenesis via NEUROG2-dependent direct inhibition of OLIG2 expression
    • cell & other
    REGULATION
    inhibited by NEUROG2 and ASCL1 are inhibited by CBFA2T2 and CBFA2T3, and less efficiently by RUNX1T1
    Phosphorylated by phosphorylated on multiple serine-proline sites in response to rising cyclin-dependent kinase (cdk) levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS