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FLASH GENE

Symbol

NTRK1

contributors: mct/ - updated : 11-10-2015

HGNC name	neurotrophic tyrosine kinase, receptor, type 1
HGNC id	8031

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HSAN4

related resource

Mutation Database of Inherited Peripheral Neuropathies

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in association with EPHB6, EFNB2, EFNB3 in low grade neuroblastoma tumoral   deletion     in thyroid tumor tumoral fusion       chimeric protein of fusion between NTRK1 and one among tropomyosin, TRP or TAG in thyroid tumor constitutional         total absence of the expression in keratoconus (repression by Sp3 transcription factor) tumoral     --over   enhances the tumorigenic properties of breast cancer cells constitutional     --low   levels of both NGF protein in seminal plasma and NTRK1 mRNA in spermatozoa are low in samples from oligoasthenozoospermic men

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   potential target for therapeutic in t(8;21) positive leukemia

ANIMAL & CELL MODELS