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FLASH GENE
Symbol MSH6 contributors: mct - updated : 15-09-2016
HGNC name mutS homolog 6 (E. coli)
HGNC id 7329
ASSOCIATED DISORDERS
corresponding disease(s) HNPCC5 , CMMRD
related resource Hereditary Non-Polyposis Colorectal Cancer, HNPCC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in sporadic colorectal cancer (early onset), putatively in Mt DNA metabolism
tumoral germinal mutation      
in early-onset colorectal cancer patients without family history and endometrial carcinoma
tumoral     --low  
in cervical cancer
tumoral       loss of function
in colon and uterus tumor
tumoral germinal mutation      
associated with Lynch syndrome cancers (accountng for 10-20p100 of Lynch syndrome colorectal cancers)
tumoral germinal mutation     loss of function
in patients with primary ovarian, fallopian tube, or peritoneal cancers
Susceptibility to prostate cancer
Variant & Polymorphism other rare genetic variants that confer a high risk of prostate cancer when mutated
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS