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FLASH GENE
Symbol GPRIN1 contributors: mct - updated : 15-10-2013
HGNC name G protein-regulated inducer of neurite outgrowth 1
HGNC id 24835
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific SELECTED Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gprin1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • with GPRIN1 and GPRIN3, may function as a downstream effector for GNAO1 to regulate neurite growth
  • signaling molecule coexpression of which with constitutively active form of GNAO1 can stimulate neurite extensions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    GNAO1-GPRIN1 pathway could mediate significant roles in neuronal migration and differentiation at embryonic stages and exert functions in wiring and/or maintenance of specific neural circuitries at postnatal to adult stages
  • modulates SPRY2 repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functions as a downstream target for GNAO1 (binding of activated GNAO1 to GPRIN1 induces activation of CDC42, which leads to morphological changes in neuronal cells)
  • SPRY2 is an interacting partner of GPRIN1
  • GNAO1 interacts with GPRIN1 and outcompetes GPRIN1 from bound SPRY2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS