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FLASH GENE

Symbol

SLCO4C1

contributors: - updated : 18-04-2005

HGNC name	solute carrier organic anion transporter family, member 4C1
HGNC id	23612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory glomerular epithelium     Epithelial absorptive excretory renal tubular epithelium

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane domains with intracellular N and C termini
	two potential ATP-binding Walker A motifs in the cytosolic portion between transmembrane domains 6 and 7
	four putative N-glycosylation sites in the extracellular loops
	five potential cytosolic phosphorylation sites

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

transporting the cardiac glycosides digoxin and ouabain, the thyroid hormones triiodothyronine and thyroxine, cAMP, and methotrexate in a sodium-independent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS