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FLASH GENE
Symbol SHISA5 contributors: mct - updated : 20-11-2009
HGNC name shisa homolog 5 (Xenopus laevis)
HGNC id 30376
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • . an N-terminal signal sequence
  • a MYB DNA-binding domain repeat
  • a central transmembrane domain composed of 18 hydrophobic amino acids
  • a proline/tyrosine domain required for endoplasmic reticulum (ER) localization
  • PRD C-terminal region containing the PDCD6 binding site
    • HOMOLOGY
    interspecies ortholog to murine Scotin
    Homologene
    FAMILY
  • shisa protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in positive regulation of I-kappaB kinase/NF-kappaB cascade
  • pro-apoptotic gene, induced upon DNA damage or cellular stress in a TP53-dependent manner, and one of the ways by which Scotin induces apoptosis is by causing cell cycle arrest
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TP53
  • PDCD6 target protein ( binding of PDCD6 to Scotin was demonstrated to be strictly calcium dependent indicating a role of this interaction in calcium signaling pathways)
  • TP63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction
  • interacting with TP73 (induces ER stress via the direct transactivation of Scotin)
  • interacts with PDCD6
    • cell & other
    REGULATION
    activated by p53
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS