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FLASH GENE
Symbol MOB2 contributors: mct/ - updated : 10-02-2011
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila Mob1
Homologene
FAMILY
  • MOB1/phocein family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • may play a novel role in cell cycle regulation
  • STK3-, FRY-, and MOB2-mediated activation of STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells
  • interferes with the activation of ectopic and endogenous STK38/STK38L by membrane-targeted MOBKL1A in an STK38 binding-dependent manner
  • has inhibitory effects on STK38/STK38L functions
  • a negative regulator of STK38/STK38L in biochemical and biological settings
  • negatively affects centrosome overduplication during S phase in an STK38 binding-dependent manner
  • potential role in mediating neurite formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component integral component of signaling pathways controlling important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation in eukaryotes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STK38 and STK38L (this association dramatically stimulates STK38 and STK38L catalytic activity)
  • interacting with MAD2L2
  • bound to the N-terminal region of STK38
  • preferentially associates with unphosphorylated STK38 and, in contrast, MOBKL1A, MOBKL1B associates with phosphorylated STK38
  • MOB2 is a negative regulator of STK38/STK38L in biochemical and biological settings
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    led to cell cycle arrest at G0/G1 phase and therefore inhibited cell proliferation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • function of Drosophila mob2 in photoreceptor morphogenesis