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FLASH GENE

Symbol

MOB2

contributors: mct/ - updated : 10-02-2011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.26 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_053005 4 - 1516 NP_443731 26 237 - 2004 15067004 NM_001172223 5 - 1707 NP_001165694 - 268 - 2004 15067004

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Lymphoid/Immune thymus       highly Reproductive male system prostate     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to Drosophila Mob1

Homologene

FAMILY

MOB1/phocein family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
	intracellular,nuclear envelope

basic FUNCTION	may play a novel role in cell cycle regulation
	STK3-, FRY-, and MOB2-mediated activation of STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells
	interferes with the activation of ectopic and endogenous STK38/STK38L by membrane-targeted MOBKL1A in an STK38 binding-dependent manner
	has inhibitory effects on STK38/STK38L functions
	a negative regulator of STK38/STK38L in biochemical and biological settings
	negatively affects centrosome overduplication during S phase in an STK38 binding-dependent manner
	potential role in mediating neurite formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

integral component of signaling pathways controlling important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation in eukaryotes

INTERACTION

DNA

RNA

small molecule

protein	STK38 and STK38L (this association dramatically stimulates STK38 and STK38L catalytic activity)
	interacting with MAD2L2
	bound to the N-terminal region of STK38
	preferentially associates with unphosphorylated STK38 and, in contrast, MOBKL1A, MOBKL1B associates with phosphorylated STK38
	MOB2 is a negative regulator of STK38/STK38L in biochemical and biological settings

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   led to cell cycle arrest at G0/G1 phase and therefore inhibited cell proliferation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

function of Drosophila mob2 in photoreceptor morphogenesis