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FLASH GENE

Symbol

GOLT1B

contributors: mlc - updated : 19-12-2007

HGNC name	golgi transport 1 homolog B (S. cerevisiae)
HGNC id	20175

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p12.1      Physical location : 21.654.698 - 21.671.337
Synonym name	granulosa cell tumorigenesis gene 2
Synonym symbol(s)	GOT1, CGI-141, YMR292W, GCT2

DNA

TYPE	functioning gene
STRUCTURE	16.00 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 2945 - 138 - Clark (2003)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Reproductive female system placenta     moderately Urinary bladder       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

UPF0198 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	involved in positive regulation of I-kappaB kinase/NF-kappaB cascade
	acting as a signal transducer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	vesicle-mediated transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in testicular seminoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS