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FLASH GENE

Symbol

ZSWIM6

contributors: mct - updated : 28-08-2015

HGNC name	zinc finger, SWIM domain containing 6
HGNC id	29316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SWIM-type zinc finger domain
	a BC-box (72–79 aa),
	a Cul2-box (99–107 aa),
	a Cut8/STS1-like domain (285–482 aa),
	and a C-terminal Sin-3 like domain (1.148–1.215 aa)

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION

basic FUNCTION	key role for ZSWIM6 in neuronal development and function, in addition to its putative roles in limb and craniofacial development
	role for ZSWIM6 in brain development and function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AFND

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Zswim6 knockout mice have abnormal neocortical and striatal development with reduced cortical and striatal volumes, and alterations in the number and structure of medium spiny neurons in the striatum