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FLASH GENE
Symbol METTL14 contributors: mct/npt - updated : 05-11-2019
HGNC name methyltransferase like 14
HGNC id 29330
Location 4q26      Physical location : 119.606.573 - 119.632.075
Synonym name
  • hypothetical protein LOC57721
  • KIAA1627
  • Synonym symbol(s) KIAA1627, hMETTL14
    EC.number 2.1.1.-/2.1.1.62
    DNA
    TYPE functioning gene
    STRUCTURE 25.52 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2138 52 456 - 2018 30006613
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal RGG repeats of METTL14 are required for METTL3/14 activity by contributing to RNA substrate binding
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • METTL3/METTL14 is found in the nucleus where it is localized to nuclear speckles and the splicing regulator WTAP is required for this distinct nuclear localization pattern
  • basic FUNCTION
  • methyltransferase activity
  • METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition
  • METTL3 is the catalytic subunit of the complex, whereas METTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    nucleobase, nucleoside, nucleotide and nucleic acid metabolism
    a component
  • RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis
  • trimer N-6-methyltransferase METTL3-METTL14-WTAP complex is linked to such critical biological processes as cell differentiation, proliferation, and death
  • METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase
  • acute METTL14 deficiency in beta-cells induces glucose intolerance by increasing the ERN1/XBP1 pathway
  • mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets (e.g., MYB and MYC) through N6-methyladenosine (m6A)modification, while the protein itself is negatively regulated by SPI1
  • YAP1 is a direct target of METTL14 in acute kidney injury (AKI) progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    METTL14, YTHDF3 and ALKBH5 were downregulated in Colorectal cancer
    tumoral     --low  
    of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS