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FLASH GENE
Symbol PRR5 contributors: mct/npt - updated : 31-01-2012
HGNC name proline rich 5 (renal)
HGNC id 31682
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   highly
Lymphoid/Immunespleen   moderately
Nervousbrain   highly
Reproductivefemale systembreastmammary gland moderately
 male systemtestis  moderately
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • PROTOR family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulates platelet-derived growth factor receptor beta expression and signaling
  • is not important for the mTOR-rictor interaction and mTOR activity toward AKT1 phosphorylation
  • may play a role in enabling mTORC2 to efficiently activate SGK1, at least in the kidney
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of mTOR complex 2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RICTOR, but not RAPTOR, and the interaction is independent of FRAP1 and not disturbed under conditions that disrupt the FRAP1-RICTOR interaction (Rictor-binding subunit of mTORC2)
    • cell & other
    REGULATION
    Other regulated by RICTOR
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer by hypermethylation of the promoter 1 and 1B
    tumoral     --low  
    in colorectal tumor by hypermethylation of the promoter 1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS