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FLASH GENE

Symbol

PRR5

contributors: mct/npt - updated : 31-01-2012

HGNC name	proline rich 5 (renal)
HGNC id	31682

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001017529 8 - 1726 42 388 ubiquitous 2007 17461779 PRR5 I1 or V5 first ATG in exon 1B NM_001017528 9 - 1843 41 379 brain, kidney 2007 17461779 translation from the second in-frame ATG in the 3' of exon 1B PRR5 I2 or V3 NM_001017530 8 - 1900 32 293 kidney 2007 17461779 PRR5 I3 or V4 translation initiation from the third ATG truncating 95 AA from -terminus (exon 1A) NM_015366 9 - 2017 - 379 - 2007 17461779 NM_181333 8 - 1878 - 388 - 2007 17461779 NM_001198721 10 - 2574 - 411 - 2007 17461779

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   liver       highly Lymphoid/Immune spleen       moderately Nervous brain       highly Reproductive female system breast mammary gland   moderately   male system testis     moderately Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

PROTOR family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	regulates platelet-derived growth factor receptor beta expression and signaling
	is not important for the mTOR-rictor interaction and mTOR activity toward AKT1 phosphorylation
	may play a role in enabling mTORC2 to efficiently activate SGK1, at least in the kidney

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of mTOR complex 2

INTERACTION

DNA

RNA

small molecule

protein

interacts with RICTOR, but not RAPTOR, and the interaction is independent of FRAP1 and not disturbed under conditions that disrupt the FRAP1-RICTOR interaction (Rictor-binding subunit of mTORC2)

cell & other

REGULATION

Other

regulated by RICTOR

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancer by hypermethylation of the promoter 1 and 1B tumoral     --low   in colorectal tumor by hypermethylation of the promoter 1B

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS