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FLASH GENE
Symbol PRR5 contributors: mct/npt - updated : 31-01-2012
HGNC name proline rich 5 (renal)
HGNC id 31682
DNA
TYPE functioning gene
SPECIAL FEATURE
text centromeric to ARHGAP8
STRUCTURE 69.13 kb     9 Exon(s)
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure three promoters, exon 1 in the brain, exon 1A in the kidney, exon 1B ubiquitous
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1726 42 388 ubiquitous 2007 17461779
  • PRR5 I1 or V5
  • first ATG in exon 1B
    • 9 - 1843 41 379 brain, kidney 2007 17461779
  • translation from the second in-frame ATG in the 3' of exon 1B
  • PRR5 I2 or V3
    • 8 - 1900 32 293 kidney 2007 17461779
  • PRR5 I3 or V4
  • translation initiation from the third ATG truncating 95 AA from -terminus (exon 1A)
    • 9 - 2017 - 379 - 2007 17461779
    8 - 1878 - 388 - 2007 17461779
    10 - 2574 - 411 - 2007 17461779
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     liver   highly
    Lymphoid/Immunespleen   moderately
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland moderately
     male systemtestis  moderately
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • PROTOR family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulates platelet-derived growth factor receptor beta expression and signaling
  • is not important for the mTOR-rictor interaction and mTOR activity toward AKT1 phosphorylation
  • may play a role in enabling mTORC2 to efficiently activate SGK1, at least in the kidney
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of mTOR complex 2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RICTOR, but not RAPTOR, and the interaction is independent of FRAP1 and not disturbed under conditions that disrupt the FRAP1-RICTOR interaction (Rictor-binding subunit of mTORC2)
    • cell & other
    REGULATION
    Other regulated by RICTOR
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer by hypermethylation of the promoter 1 and 1B
    tumoral     --low  
    in colorectal tumor by hypermethylation of the promoter 1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS