SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,nucleus,chromatin/chromosome,centromere
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| text
| DNA damage induced by UV or methyl methane sulfonate caused translocation from cytoplasm to nucleus |
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a pool of BRSK1, but not BRSK2 or LKB1, localizes at membrane lipid rafts  |
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is specifically localized to neuromuscular junctions |
| basic FUNCTION
| acting as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate |
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required for neuronal polarization |
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role in the control of centrosome biogenesis and essential for centriole duplication |
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its kinase activity controls centrosome homeostasis by regulating phosphorylation of TUBG1 |
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BRSK2 and BRSK1 (its homologue, SAD-B) kinases may regulate neuronal polarization, presynaptic vesicle clustering and axon termination |
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BRSK1, BRSK2 are crucial for establishing neuronal polarity, and BRSK1 has also been shown to regulate neurotransmitter release presynaptically |
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BRSK1, BRSK2 are required for axon specification and arborization in subsets of neurons |
