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FLASH GENE
Symbol BRSK1 contributors: shn/npt/pgu - updated : 24-02-2015
HGNC name BR serine/threonine kinase 1
HGNC id 18994
Location 19q13.42      Physical location : 55.795.533 - 55.823.901
Synonym name
  • SAD1 kinase
  • protein kinase SAD1A
    • Synonym symbol(s) KIAA1811, FLJ43009, SAD-B, SAD1, SADB
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 28.37 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D19S880 - D19S605 - BRSK1 - D19S877 - D19S891 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3109 - 778 gray matter of the brain, spinal cord, in both axonal and dendritic processes of cultured hippocampal 2005 15705853
    - - - - - localize to centrosomes, where it controls centrosome duplication 2013 24047693
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicorpus callosum moderately
     brainlimbic systemhippocampus highly
     braindiencephalonamygdala moderately
     brainbasal nucleicaudate nucleus highly
     brainmidbrainsubstantia nigra highly
     braindiencephalonthalamus highly
     brainhindbraincerebellum highly
     spinal cord   highly
    Reproductivefemale systemovary  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one UBA domain
    • HOMOLOGY
    interspecies ortholog to Brsk1, Mus musculus
    ortholog to Brsk1, Rattus norvegicus
    intraspecies paralog to BRSK2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • AMPK subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • DNA damage induced by UV or methyl methane sulfonate caused translocation from cytoplasm to nucleus
  • a pool of BRSK1, but not BRSK2 or LKB1, localizes at membrane lipid rafts
  • is specifically localized to neuromuscular junctions
    • basic FUNCTION
  • acting as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate
  • required for neuronal polarization
  • role in the control of centrosome biogenesis and essential for centriole duplication
  • its kinase activity controls centrosome homeostasis by regulating phosphorylation of TUBG1
  • BRSK2 and BRSK1 (its homologue, SAD-B) kinases may regulate neuronal polarization, presynaptic vesicle clustering and axon termination
  • BRSK1, BRSK2 are crucial for establishing neuronal polarity, and BRSK1 has also been shown to regulate neurotransmitter release presynaptically
  • BRSK1, BRSK2 are required for axon specification and arborization in subsets of neurons
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • gamma tubulin, TUBG1
  • BRSK2, BRSK1 are required to initiate WEE1 downregulation in polarized neurons
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS