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FLASH GENE

Symbol

TSPYL5

contributors: mct - updated : 08-03-2010

HGNC name	TSPY-like 5
HGNC id	29367

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Tspyl5 (73.8pc)
	homolog to rattus Tspyl5 (72.4pc)

Homologene

FAMILY

nucleosome assembly protein (NAP) family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome,nucleosome

basic FUNCTION	involved in nucleosome assembly
	involved in cell growth and resistance to radiation via the regulation of p21 and PTEN/AKT pathway (Kim 2010)
	suppressor of TP53 function through its interaction with USP7

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacts with ubiquitin-specific protease 7 (USP7), deubiquitylase for the TP53 tumour suppressor and TSPYL5 reduces the activity of USP7 towards TP53, resulting in increased TP53 ubiquitylation

cell & other

REGULATION

activated by

by LH in the primate corpus luteum

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   inactivated by DNA hypermethylation(Jung 2008)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	could be a putative epigenetic target gene in gastric cancers (Jung 2008)

ANIMAL & CELL MODELS