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FLASH GENE
Symbol GYLTL1B contributors: mct - updated : 07-07-2014
HGNC name glycosyltransferase-like 1B
HGNC id 16522
Location 11p11.2      Physical location : 45.943.195 - 45.950.647
Synonym name like-glycosyltransferase 2
Synonym symbol(s) FLJ35207, LARGE2, PP5656
DNA
TYPE functioning gene
STRUCTURE 7.45 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2539 - 721 - 2005 15752776
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouthtongue   
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate  highly Homo sapiens
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two catalytic domains with homology to members of glycosyltransferase families GT8 and GT49
  • a transmembrane domain
  • HOMOLOGY
    intraspecies paralog to LARGE
    Homologene
    FAMILY glycosyltransferase 8 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • facilitating the maturation of alpha-dystroglycan more effectively than LARGE (stimulating hyperglycosylation) and increasing its affinity for laminin binding
  • participating in glycosylation of alpha-dystroglycan
  • may carry out the synthesis of glycoprotein
  • and glycosphingolipid sugar chains
  • LARGE and GYLTL1B catalyze the same glycosylation reactions for the functional modification of DAG1, but that they have different biochemical properties
  • catalyzes the same glycosylation reaction as LARGE
  • LARGE and GYLTL1B may be functionally redundant
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates functional DAG1 glycosylation in prostate cancer cell lines
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the context of prostate cancer, and its reduction correlates with disease progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic biomarker in prostate carcinoma
  • Therapy target
    ANIMAL & CELL MODELS