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Symbol NKX2-6 contributors: mct - updated : 05-07-2017
HGNC name NK2 transcription factor related, locus 6 (Drosophila)
HGNC id 32940
Corresponding disease
CART persistent truncus arteriosus
Location 8p21.2      Physical location : 23.559.964 - 23.563.922
Synonym name
  • homeobox protein NKX2-6
  • tinman paralog (Drosophila)
    • Synonym symbol(s) LOC137814, CSX2, NKX4-2
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text caudal pharyngeal arches, branchial arch mesectoderm and ectoderm
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • NK-2 homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be playing a role in heart development, in the process of outflow tract
  • homeodomain transcription factor crucial for cardiovascular development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with NKX2-5, TBX and GATA family proteins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CART
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS