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FLASH GENE
Symbol FCRL2 contributors: mct/npt - updated : 22/11/2008
HGNC name Fc receptor like 2
HGNC id 14875
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three Ig-like domains
  • a C-terminal mucin-like domain containing a conserved alpha-helical motif with dileucine signals
    • HOMOLOGY
    intraspecies homolog to FCRL/FREB/FcRX
    Homologene
    FAMILY
  • FcR family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be up-regulated in the progression of melanocytic tumors
  • has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in B-cell chronic lymphocytic leukemia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    melanoma in progression
    tumoral     --other  
    in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential implication of FCRL2 immunotherapeutic interventions
    ANIMAL & CELL MODELS