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FLASH GENE

Symbol

FCRL2

contributors: mct/npt - updated : 22/11/2008

HGNC name	Fc receptor like 2
HGNC id	14875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	31.38 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 12 - 2573 - 255 - Kazemi (2008) variant 1 7 - 2071 - 508 - Kazemi (2008) FCRL2A - splicing 1298 - 426 - Chikaev FCRL2B1 - splicing 1153 - 318 - Chikaev FCRL2B2 - splicing 1132 - 311 - Chikaev FCRL2C1 - splicing 1194 - 275 - Chikaev FCRL2C2 - splicing 1173 - 268 - Chikaev

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Lymphoid/Immune lymph node           spleen           thymus           tonsils         Skin/Tegument skin

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three Ig-like domains
	a C-terminal mucin-like domain containing a conserved alpha-helical motif with dileucine signals

HOMOLOGY

intraspecies

homolog to FCRL/FREB/FcRX

Homologene

FAMILY

FcR family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be up-regulated in the progression of melanocytic tumors
	has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in B-cell chronic lymphocytic leukemia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   melanoma in progression tumoral     --other   in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	potential implication of FCRL2 immunotherapeutic interventions

ANIMAL & CELL MODELS