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FLASH GENE
Symbol CRYBA2 contributors: mct - updated : 26-10-2018
HGNC name crystallin, beta A2
HGNC id 2395
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyelens   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, lens
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • an ABAB pattern, structural motif characteristic of the beta-gamma crystallin superfamily
  • greek key motifs
    • mono polymer homomer , heteromer , dimer , aggregate
    HOMOLOGY
    interspecies ortholog to murine Cryba2
    homolog to C.elegans F40G9.8
    Homologene
    FAMILY
  • crystallin superfamily
  • beta/gamma cristallin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • contributing to the refractive index and transparency of lens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dominant structural components of the vertebrate eye lens
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADCC6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • strong candidate gene for age-related cataracts, and the slightly smaller size of the lens might be recognized as an early biomarker for age-related cataracts
    • Marker
    Therapy target
    ANIMAL & CELL MODELS