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FLASH GENE
Symbol POLR3B contributors: mct - updated : 20-01-2021
HGNC name polymerase (RNA) III (DNA directed) polypeptide B
HGNC id 30348
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc-finger
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Polr3b
    Homologene
    FAMILY
  • RNA polymerase beta chain family
    • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DNA-directed RNA polymerase activity
  • transferase activity
  • plays essential role in spindle formation and cell-cycle progression
  • is a conserved protein that localizes at nucleus in interphase cells and at mitotic apparatus in mitotic cells
  • may modulate the function of (a) key protein(s) in mitotic apparatus
  • is a model regulator of CENPB and likely POLR3B regulates mitosis through modulating CENPB-mediated centromere organization
  • essential role likely of POLR3B in orchestrating the maintenance of the intestinal crypt during early postnatal development
  • encodes the second-largest catalytic subunit of RNA polymerase III, an enzyme involved in transcription
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • second largest component of RNA polymerase III which consisting of about 15 different subunits
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacts with CENPB and promotes cleavage of the N-terminal DNA binding domain from CENPB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HCAHC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS