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FLASH GENE

Symbol

POLR3B

contributors: mct - updated : 20-01-2021

HGNC name	polymerase (RNA) III (DNA directed) polypeptide B
HGNC id	30348

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	152.54 kb     28 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018082 28 - 4286 - 1133 - 2002 12391170 NM_001160708 28 - 4133 - 1075 - 2002 12391170

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

zinc-finger

mono polymer

complex

HOMOLOGY

interspecies

ortholog to murine Polr3b

Homologene

FAMILY

RNA polymerase beta chain family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	DNA-directed RNA polymerase activity
	transferase activity
	plays essential role in spindle formation and cell-cycle progression
	is a conserved protein that localizes at nucleus in interphase cells and at mitotic apparatus in mitotic cells
	may modulate the function of (a) key protein(s) in mitotic apparatus
	is a model regulator of CENPB and likely POLR3B regulates mitosis through modulating CENPB-mediated centromere organization
	essential role likely of POLR3B in orchestrating the maintenance of the intestinal crypt during early postnatal development
	encodes the second-largest catalytic subunit of RNA polymerase III, an enzyme involved in transcription

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

second largest component of RNA polymerase III which consisting of about 15 different subunits

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

interacts with CENPB and promotes cleavage of the N-terminal DNA binding domain from CENPB

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HCAHC

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS