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FLASH GENE
Symbol POLR3B contributors: mct - updated : 20-01-2021
HGNC name polymerase (RNA) III (DNA directed) polypeptide B
HGNC id 30348
Corresponding disease
HCAHC cerebral hypomyelination with cerebellar atrophy and hypoplasia of the corpus callosum
Location 12q23.3      Physical location : 106.751.435 - 106.903.974
Synonym name
  • RNA polymerase III subunit C2
  • interphase nucleus and mitotic apparatus associated protein
  • polymerase (RNA) III (DNA directed) polypeptide B
    • Synonym symbol(s) RPC2, FLJ10388, INMAP
    EC.number 2.7.7.6
    DNA
    TYPE functioning gene
    STRUCTURE 152.54 kb     28 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 4286 - 1133 - 2002 12391170
    28 - 4133 - 1075 - 2002 12391170
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc-finger
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Polr3b
    Homologene
    FAMILY
  • RNA polymerase beta chain family
    • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DNA-directed RNA polymerase activity
  • transferase activity
  • plays essential role in spindle formation and cell-cycle progression
  • is a conserved protein that localizes at nucleus in interphase cells and at mitotic apparatus in mitotic cells
  • may modulate the function of (a) key protein(s) in mitotic apparatus
  • is a model regulator of CENPB and likely POLR3B regulates mitosis through modulating CENPB-mediated centromere organization
  • essential role likely of POLR3B in orchestrating the maintenance of the intestinal crypt during early postnatal development
  • encodes the second-largest catalytic subunit of RNA polymerase III, an enzyme involved in transcription
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • second largest component of RNA polymerase III which consisting of about 15 different subunits
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacts with CENPB and promotes cleavage of the N-terminal DNA binding domain from CENPB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HCAHC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS