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FLASH GENE

Symbol

TSHZ3

contributors: mct - updated : 17-12-2011

HGNC name	teashirt zinc finger homeobox 3
HGNC id	30700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of Alzheimer disease tumoral     --low   promoter was found to be methylated in all the breast/prostate cancer cell lines

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter