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FLASH GENE
Symbol TSHZ3 contributors: mct - updated : 17-12-2011
HGNC name teashirt zinc finger homeobox 3
HGNC id 30700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • homeobox DNA-binding domain
  • C2H2-type zinc fingers
    • HOMOLOGY
    Homologene
    FAMILY
  • teashirt C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • required for proximal ureteric smooth muscle cell differentiation downstream of SHH and BMP4
  • potentially controls the development of diverse components of the circuitry required for breathing
  • TSHZ3 and SMARCE1 cooperate to modulate MYOD activity on the MYOG promoter to regulate skeletal muscle differentiation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • direct interaction of APBB1 and TSHZ3 with the promoter region of CASP4
  • SMARCE1, a subunit of the SWI/SNF complex, is a partner of TSHZ3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of Alzheimer disease
    tumoral     --low  
    promoter was found to be methylated in all the breast/prostate cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter