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FLASH GENE

Symbol

TSHZ3

contributors: mct - updated : 17-12-2011

HGNC name	teashirt zinc finger homeobox 3
HGNC id	30700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Reproductive female system ovary     highly Urinary renal pelvis       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed in the embryonic renal pelvis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	homeobox DNA-binding domain
	C2H2-type zinc fingers

HOMOLOGY

Homologene

FAMILY

teashirt C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in regulation of transcription, DNA-dependent
	required for proximal ureteric smooth muscle cell differentiation downstream of SHH and BMP4
	potentially controls the development of diverse components of the circuitry required for breathing
	TSHZ3 and SMARCE1 cooperate to modulate MYOD activity on the MYOG promoter to regulate skeletal muscle differentiation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	direct interaction of APBB1 and TSHZ3 with the promoter region of CASP4
	SMARCE1, a subunit of the SWI/SNF complex, is a partner of TSHZ3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of Alzheimer disease tumoral     --low   promoter was found to be methylated in all the breast/prostate cancer cell lines

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter