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FLASH GENE
Symbol TSHZ3 contributors: mct - updated : 17-12-2011
HGNC name teashirt zinc finger homeobox 3
HGNC id 30700
Location 19q12      Physical location : 31.765.852 - 31.840.190
Synonym name
  • zinc finger protein 537
  • teashirt family zinc finger 3
  • teashirt 3
    • Synonym symbol(s) KIAA1474, ZNF537, TSH3
    DNA
    TYPE functioning gene
    STRUCTURE 74.34 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4995 118 1081 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Reproductivefemale systemovary  highly
    Urinaryrenal pelvis   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in the embryonic renal pelvis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • homeobox DNA-binding domain
  • C2H2-type zinc fingers
    • HOMOLOGY
    Homologene
    FAMILY
  • teashirt C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • required for proximal ureteric smooth muscle cell differentiation downstream of SHH and BMP4
  • potentially controls the development of diverse components of the circuitry required for breathing
  • TSHZ3 and SMARCE1 cooperate to modulate MYOD activity on the MYOG promoter to regulate skeletal muscle differentiation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • direct interaction of APBB1 and TSHZ3 with the promoter region of CASP4
  • SMARCE1, a subunit of the SWI/SNF complex, is a partner of TSHZ3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of Alzheimer disease
    tumoral     --low  
    promoter was found to be methylated in all the breast/prostate cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter