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FLASH GENE
Symbol ITGB1BP3 contributors: npt/SGE - updated : 04-02-2010
HGNC name integrin beta 1 binding protein 3
HGNC id 17871
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Itgb1bp3 (85.1pc)
Homologene
FAMILY
  • uridine kinase family
  • NRK subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • reducing laminin matrix deposition and cell adhesion to laminin, but not to fibronectin
  • involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation
  • may play a role in the regulation of terminal myogenesis
  • catalyzing the phosphorylation of nicotinamide riboside NR and NaR to form NMN and NaMN
  • may play a rol ein the regulation of terminal myogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor , purine/pyrimidine
    signaling
  • Preiss-Handler independent NAD biosynthesis
  • pyridine nucleotide biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP binding
  • Mg2+ binding
    • protein
  • ITGB1 (alone or when associated with alpha-7)
    • cell & other
    REGULATION
    Other down-regulated during myoblast differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS