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FLASH GENE

Symbol

ITGB1BP3

contributors: npt/SGE - updated : 04-02-2010

HGNC name	integrin beta 1 binding protein 3
HGNC id	17871

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014446 - splicing 775 NP_055261 20 186 - Bieganowski (2004) ATP/GTP-binding site motif A (P-loop) NM_170678 8 splicing 1142 NP_733778 26 230 - Li (1999) also called variant 2 or NRK2 bipartite nuclear localization signal ATP/GTP-binding site motif A (P-loop)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine Itgb1bp3 (85.1pc)

Homologene

FAMILY	uridine kinase family
	NRK subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	reducing laminin matrix deposition and cell adhesion to laminin, but not to fibronectin
	involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation
	may play a role in the regulation of terminal myogenesis
	catalyzing the phosphorylation of nicotinamide riboside NR and NaR to form NMN and NaMN
	may play a rol ein the regulation of terminal myogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

cofactor , purine/pyrimidine

signaling

	Preiss-Handler independent NAD biosynthesis
	pyridine nucleotide biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	ATP binding
	Mg2+ binding

protein

ITGB1 (alone or when associated with alpha-7)

cell & other

REGULATION

Other

down-regulated during myoblast differentiation

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS