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FLASH GENE

Symbol

MIB1

contributors: mct - updated : 20-06-2016

HGNC name	mindbomb homolog 1 (Drosophila)
HGNC id	21086

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Lymphoid/Immune lymph node       highly Nervous brain       highly   spinal cord       highly Reproductive female system ovary     highly Urinary bladder       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a zinc finger
	nine ankyrin repeats
	three RING fingers
	an alpha-helical coiled-coil region between RING2 and RING3

HOMOLOGY

interspecies

ortholog to murine Mib1

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus

basic FUNCTION	involved in protein ubiquitination
	its activity is required for S3 cleavage of the NOTCH1 receptor
	essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development
	potentially important for intraembryonic hematopoiesis not only in the aortic endothelium but also in the the floor of the aorta and subaortic patches
	essential E3 ligase in T and marginal zone B cell development, through the regulation of Notch ligands in the thymic and splenic microenvironments
	multidomain E3 ligase that directs ubiquitination of the Notch ligands Delta and Jagged to promote their endocytosis
	sufficient to activate WNT/CTNNB1 signaling and that this activity depends on endogenous RYK
	both RYK and MIB1 are required for Wnt-3A-mediated activation of CTNNB1
	is required for correct proximodistal (P-D) patterning of the developing pancreas and beta-cell formation
	MIB1 modulates dynamin recruitment by regulating the interaction between SNX18 and DNM2, thereby helping to ensure the efficient signaling activity of Notch ligands

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ubiquitin ligase complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interaction between MIB1 and CFLAR decreases the association of caspase-8 with CFLAR, which activates caspase-8 and induces cell death
	vRYK both physically and functionally interacts with the E3 ubiquitin ligase Mindbomb 1 (MIB1)
	is a new component of centriolar satellites, which interacts with and ubiquitylates CEP131 and PCM1 and suppresses primary cilium formation
	interaction between MIB1 and PLK4 is a new and important element in the control of centriole homeostasis
	ubiquitin ligase MIB1 plays essential roles in Notch signaling via Notch ligand ubiquitination
	MIB1 promotes the interaction between DNM2 and SNX18 in an ubiquitin ligase activity-dependent manner
	PCM1 is essential for tethering the E3 ligase, Mindbomb1 (MIB1), to satellites

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function abrogated T and marginal zone B (MZB) cell development in the lymphopoietic niches

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS