protein
| interacts with both ATR and ATM |
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interactions of INPP5E with several ciliary and centrosomal proteins, including a recently identified ciliopathy protein centrosomal protein 164 (CEP164) |
|
components of the vesicular transport machinery, the GEF RAB3IP and the GTPase RAB8A, are interacting partners of CEP164 |
|
CEP83 specifically localizes to the distal end of the mother centriole and interacts with CEP164, a distal appendage component |
|
one of the major functions of CEP164 in ciliogenesis is to recruit active TTBK2 to centrioles |
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TTBK2 has the potential to effectively phosphorylate CEP164 and CEP97 and inhibits the interaction between CEP164 and its binding partner DVL3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner |
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CEP164 is necessary for the proper recruitment of another distal appendage/transition fiber protein Chibby1 (CBY1) and its binding partners CIBAR1 and CIBAR2 to the ciliary base in multiciliated cells |
|
NME3 binds to several NPHPs, including NEK8, CEP164, and ankyrin repeat and sterile & |
|
945; motif domain-containing 6 (ANKS6) |
|
RABL2A, RABL2B recruitment to the mother centriole is dependent on the distal appendage proteins CEP164 and CEP83 |