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FLASH GENE

Symbol

MORC2

contributors: mct - updated : 17-07-2017

HGNC name	MORC family CW-type zinc finger 2
HGNC id	23573

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001303257 26 - 5177 NP_001290186 - 1029 - - NM_001303256 26 - 5186 NP_001290185 - 1032 - - NM_014941 27 - 6052 NP_055756 - 970 - -

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately   pancreas exocrine       highly Lymphoid/Immune spleen       lowly Nervous brain       highly Reproductive female system ovary     highly   male system testis     highly Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular smooth       Muscular striatum skeletal     Nervous peripherous

cell lineage
cell lines	liver tumor
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a CW-type zinc finger
	a PRD domain, dispensable for the protein stability and subcellular localization of MORC2, but depletion of the PRD domain substantially suppressed MORC2-mediated migration, invasion, and metastasis
	derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiological substrate of p21-activated kinase 1 (PAK1), an important integrator of extracellular signals and nuclear processes

HOMOLOGY

interspecies

ortholog to murine Morc2a

Homologene

FAMILY

Microrchidia (MORC) family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	involved in several nuclear processes, including transcription modulation and DNA damage repair
	cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY
	regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis
	essential gene required for epigenetic silencing by the HUSH complex, and HUSH recruits MORC2 to target sites in heterochromatin
	chromatin remodeling protein with emerging roles in the regulation of DNA damage response and gene transcription
	promotes breast cancer invasion and metastasis through its PRD domain-mediated interaction with CTNND1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

PAK1-MORC2 axis is likely critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interaction between MORC2 and adenosine triphosphate (ATP)-citrate lyase (ACLY), an enzyme that catalyzes the formation of acetyl-coA and plays a central role in lipogenesis, cholesterogenesis, and histone acetylation
	MORC2 down-regulated CDKN1A by recruiting HDAC1 to the CDKN1A promoter, in a TP53-independent manner
	MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMT2Z , DDGRM

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS