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FLASH GENE
Symbol MORC2 contributors: mct - updated : 17-07-2017
HGNC name MORC family CW-type zinc finger 2
HGNC id 23573
Corresponding disease
CMT2Z Charcot-Marie-Tooth disease, axonal, type 2Z
Location 22q12.2      Physical location : 31.322.599 - 31.364.187
Genatlas name Microchidia protein 2
Synonym name
  • zinc finger, CW type with coiled-coil domain 1
  • Synonym symbol(s) ZCW3, ZCWCC1, KIAA0852, CMT2Z
    DNA
    TYPE functioning gene
    STRUCTURE 43.37 kb     26 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5177 - 1029 - -
    26 - 5186 - 1032 - -
    27 - 6052 - 970 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
     pancreas exocrine   highly
    Lymphoid/Immunespleen   lowly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularsmooth   
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines liver tumor
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CW-type zinc finger
  • a PRD domain, dispensable for the protein stability and subcellular localization of MORC2, but depletion of the PRD domain substantially suppressed MORC2-mediated migration, invasion, and metastasis
  • derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiological substrate of p21-activated kinase 1 (PAK1), an important integrator of extracellular signals and nuclear processes
  • HOMOLOGY
    interspecies ortholog to murine Morc2a
    Homologene
    FAMILY Microrchidia (MORC) family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in several nuclear processes, including transcription modulation and DNA damage repair
  • cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY
  • regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis
  • essential gene required for epigenetic silencing by the HUSH complex, and HUSH recruits MORC2 to target sites in heterochromatin
  • chromatin remodeling protein with emerging roles in the regulation of DNA damage response and gene transcription
  • promotes breast cancer invasion and metastasis through its PRD domain-mediated interaction with CTNND1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • PAK1-MORC2 axis is likely critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interaction between MORC2 and adenosine triphosphate (ATP)-citrate lyase (ACLY), an enzyme that catalyzes the formation of acetyl-coA and plays a central role in lipogenesis, cholesterogenesis, and histone acetylation
  • MORC2 down-regulated CDKN1A by recruiting HDAC1 to the CDKN1A promoter, in a TP53-independent manner
  • MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2Z
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS