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FLASH GENE
Symbol NELF contributors: mct/npt - updated : 14-06-2008
HGNC name nasal embryonic LHRH factor
HGNC id 29843
Corresponding disease
HHI2 hypogonadism, isolated hypogonadotropic, 2
Location 9q34.3      Physical location : 140.342.024 - 140.353.786
Synonym name
  • nasal embryonic luteinizing hormone-releasing hormone factor
  • Synonym symbol(s) RP11-48C7.1, MGC125369
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC48935 9q34.3 hypothetical protein MGC48935 LOC203235 9q34.3 hypothetical LOC203235 PTGDS 9q34.2-q34.3 prostaglandin D2 synthase 21kDa (brain) LOC286257 9q34.3 hypothetical protein LOC286257 CLIC3 9q34.3 chloride intracellular channel 3 ABCA2 9q34.3 ATP-binding cassette, sub-family A (ABC1), member 2 FUT7 9q34.3 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) LOC389814 9 similar to LPAL6438 NPDC1 9q34.3 neural proliferation, differentiation and control, 1 ENTPD2 9q34 ectonucleoside triphosphate diphosphohydrolase 2 LOC89958 9q34.3 hypothetical protein LOC89958 LOC91373 MAN1B1 9q34 mannosidase, alpha, class 1B, member 1 DPP7 9q34.3 dipeptidylpeptidase 7 LOC389815 9 LOC389815 GRIN1 9q34.3 glutamate receptor, ionotropic, N-methyl D-aspartate 1 LOC389816 9 similar to CDNA sequence BC004853 LOC389817 9 LOC389817 ANAPC2 9q34.3 LOC389817 SSNA1 9q34.3 Sjogren's syndrome nuclear autoantigen 1 C9orf75 9q34.3 chromosome 9 open reading frame 75 MGC14327 9q34.3 hypothetical protein MGC14327 NELF 9q34.3 nasal embryonic luteinizing hormone-releasing hormone factor FLJ43070 9q34.3 FLJ43070 protein MRPL41 9q34.3 mitochondrial ribosomal protein L41 LOC92715 9q34.3 hypothetical protein BC017335 ZMYND19 9q34.3 zinc finger, MYND domain containing 19 MGC40555 C9orf37 9q34.3 chromosome 9 open reading frame 37 LOC392402 9 similar to protein phosphatase 2A inhibitor-2 I-2PP2A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2987 - 530 - Miura, 2004
    15 splicing 2972 59.9 528 - Miura (2004), Lim (2007)
    - splicing 2918 - 507 - Miura, 2004
    - splicing 2897 - 500 - Miura, 2004
    - splicing 3223 - 402 - Miura, 2004
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   highly
     stomach   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Skeleton    moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
  • meningioma
  • moderately differentiated adenocarcinoma
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Nelf
    ortholog to rattus Nelf
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role as a common guidance molecule for olfactory axon projections in the neurophilic migration of LHRH cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHI2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS