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FLASH GENE

Symbol

FASTK

contributors: - updated : 14-02-2005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q35      Physical location : 150.773.707 - 150.777.951
Genatlas name	FAST kinase
Synonym symbol(s)	FAST, FLJ13079
EC.number	2.7.1.-

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1866 61 549 - Scherer the longest transcript variant 4 - - 1443 - 408 - Scherer lacks an alternate in-frame exon resulting in a shorter isoform

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Reproductive female system placenta       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a kinase domain
	a proline-rich SH3-binding domain

HOMOLOGY

interspecies

homolog to murine Fastk

Homologene

FAMILY

serine/threonine protein kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

phosphorylating and activating TIA1, resulting in induction of apoptosis

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to TIA1

cell & other

REGULATION

activated by

dephosphorylation

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS