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FLASH GENE
Symbol MYLPF contributors: mct/npt - updated : 15-09-2020
HGNC name myosin light chain, phosphorylatable, fast skeletal muscle
HGNC id 29824
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two EF-hand calcium-binding domains
    • HOMOLOGY
    interspecies ortholog to murine Mylpf
    homolog to zebrafish mylpfa
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in muscle development
  • is critically important for fast and slow skeletal muscle development
  • MYLPF function is essential for muscle integrity during early development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOA-mediated MYLPF regulates likely the actin organization for cytokinesis during oocyte maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice homozygous for a null mylpf allele lack all skeletal muscle at birth