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FLASH GENE
Symbol NANOS3 contributors: mct/npt/pgu - updated : 01-06-2016
HGNC name nanos homolog 3 (Drosophila)
HGNC id 22048
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc finger motif
    • HOMOLOGY
    Homologene
    FAMILY
  • nanos gene family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • highest in germ cell nuclei where the protein co-localized with chromosomal DNA during mitosis/meiosis
    • basic FUNCTION
  • having a conserved function in germ cell development
  • is able to delay the cell cycle progression of spermatogonial cells
  • in the prepuberal testis, is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle
  • essential protein required for the germ cell maintenance
  • with TIAL1 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
  • functions in human germ cell development
  • modulates essential aspects of human germ cell development perhaps during the cell cycle
  • NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TIAL1 would play critical functions
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly alter the germ cell number and expression patterns of genes that regulate important germ cell properties, including maintenance of pluripotency, germ cell development and meiotic progression
    constitutional germinal mutation      
    in Primary ovarian insufficiency (POI)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS