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FLASH GENE
Symbol NANOS3 contributors: mct/npt/pgu - updated : 01-06-2010
HGNC name nanos homolog 3 (Drosophila)
HGNC id 22048
Location 19p13.13      Physical location : 13.987.949 - 13.991.570
Synonym name nanos homolog 3
Synonym symbol(s) NOS3, NANOS1L, MGC120114
DNA
TYPE functioning gene
STRUCTURE 3.62 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor) LYL1 19p13.2-p13.1 lymphoblastic leukemia derived sequence 1 FLJ20244 19p13.13 hypothetical protein FLJ20244 BTBD14B 19p13.13 BTB (POZ) domain containing 14B STX10 19p13.2 syntaxin 10 ETR101 LOC390891 19 similar to 60S RIBOSOMAL PROTEIN L12 CACNA1A 19p13.2-13.1 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit MGC10471 19p13.13 hypothetical protein MGC10471 MGC3207 19p13.13 hypothetical protein MGC3207 HSPC023 19p13.13 HSPC023 protein ZSWIM4 19p13.13 zinc finger, SWIM domain containing 4 NANOS3 19p13.13 nanos homolog 3 (Drosophila) MGC11271 19p13.13 hypothetical protein MGC11271 FLJ20241 19p13.13 putative NFkB activating protein FLJ23447 19p13.13 hypothetical protein FLJ23447 LOC90379 19p13.13 hypothetical protein BC002926 RFX1 19p13.1 regulatory factor X, 1 (influences HLA class II expression) RLN3 19p13.2 relaxin 3 (H3) WSX1 LOC342979 19p13.13 hypothetical LOC342979 LOC126037 19p13.13 similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein LOC113230 19p13.13 hypothetical protein LOC113230 PRKACA 19p13.1 protein kinase, cAMP-dependent, catalytic, alpha ASF1B 19p13.12 ASF1 anti-silencing function 1 homolog B (S. cerevisiae) LPHN1 19p13.2 latrophilin 1 CD97 19p13.2-p13.12 CD97 antigen DDX39 19p13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 PRKCL1 19p13.1-p12 protein kinase C-like 1 PTGER1 19p13.1 prostaglandin E receptor 1 (subtype EP1), 42kDa RGS19IP1 19p13.2-p13.1 regulator of G-protein signalling 19 interacting protein 1 DNAJB1 19p13.2 DnaJ (Hsp40) homolog, subfmaily B, member 1 GPSN2 19p13.12 glycoprotein, synaptic 2 NDUFB7 19p13.12-p13.11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa LOC388512 19 similar to Asialoglycoprotein receptor 2 (Hepatic lectin H2) (ASGP-R) (ASGPR) EMR3 19p13.1 egf-like module containing, mucin-like, hormone receptor-like 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 946 - 192 - 2003 12947200
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly Homo sapiens
 male systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductiveoocyte Homo sapiens
Reproductivespermatogonia Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text
  • expressed in both male and female gonads of early embryo and, after birth, it is found only in the testis
  • enriched in the fetal ovary, testis and brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger motif
  • HOMOLOGY
    Homologene
    FAMILY
  • nanos gene family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • highest in germ cell nuclei where the protein co-localized with chromosomal DNA during mitosis/meiosis
  • basic FUNCTION
  • having a conserved function in germ cell development
  • is able to delay the cell cycle progression of spermatogonial cells
  • in the prepuberal testis, is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle
  • essential protein required for the germ cell maintenance
  • with TIAL1 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
  • functions in human germ cell development
  • modulates essential aspects of human germ cell development perhaps during the cell cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TIAL1 would play critical functions
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS