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FLASH GENE

Symbol

NANOS3

contributors: mct/npt/pgu - updated : 01-06-2016

HGNC name	nanos homolog 3 (Drosophila)
HGNC id	22048

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.13      Physical location : 13.987.949 - 13.991.570
Synonym name	nanos homolog 3
Synonym symbol(s)	NOS3, NANOS1L, MGC120114

DNA

TYPE	functioning gene
STRUCTURE	3.62 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098622 2 - 946 NP_001092092 - 192 - 2003 12947200

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary     highly Homo sapiens   male system testis     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens Reproductive oocyte Homo sapiens Reproductive spermatogonia Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	expressed in both male and female gonads of early embryo and, after birth, it is found only in the testis
	enriched in the fetal ovary, testis and brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a zinc finger motif

HOMOLOGY

Homologene

FAMILY

nanos gene family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
text	highest in germ cell nuclei where the protein co-localized with chromosomal DNA during mitosis/meiosis

basic FUNCTION	having a conserved function in germ cell development
	is able to delay the cell cycle progression of spermatogonial cells
	in the prepuberal testis, is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle
	essential protein required for the germ cell maintenance
	with TIAL1 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
	functions in human germ cell development
	modulates essential aspects of human germ cell development perhaps during the cell cycle
	NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

TIAL1 would play critical functions

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   significantly alter the germ cell number and expression patterns of genes that regulate important germ cell properties, including maintenance of pluripotency, germ cell development and meiotic progression constitutional germinal mutation       in Primary ovarian insufficiency (POI)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS