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FLASH GENE
Symbol NANOS2 contributors: mct/npt - updated : 02-09-2009
HGNC name nanos homolog 2 (Drosophila)
HGNC id 23292
Location 19q13.32      Physical location : 46.416.474 - 46.418.036
Synonym name nanos homolog 2
Synonym symbol(s) NOS2
DNA
TYPE functioning gene
STRUCTURE 1.56 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
FOSB 19q13.3 FBJ murine osteosarcoma viral oncogene homolog B RTN2 19q13.3 reticulon 2 VASP 19q13.2-q13.3 vasodilator-stimulated phosphoprotein FLJ40125 19q13.32 hypothetical protein FLJ40125 OPA3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) GPR4 19q13.3 G protein-coupled receptor 4 EML2 19q13.32 echinoderm microtubule associated protein like 2 GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin FOXA3 19q13.2-q13.4 forkhead box A3 IRF2BP1 19q13.32 interferon regulatory factor 2 binding protein 1 LOC339344 19q13.32 hypothetical protein LOC339344 NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein LOC339346 19q13.33 similar to histidine secretory acid phosphatase LOC388555 19 similar to RPRC483 LOC126052 19q13.33 TGFB-induced factor (TALE family homeobox) pseudogene LOC147920 19q13.33 similar to VPRI645 LOC390944 19 similar to 60S ribosomal protein L12 UNQ644 19q13.33 APRG644 HIF3A 19q13.33 hypoxia inducible factor 3, alpha subunit PPP5C 19q13.3 protein phosphatase 5, catalytic subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1577 - 138 - Kusz (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in prenatal germ cells and at later stages in spermatogenesis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved zinc-finger domain
  • HOMOLOGY
    Homologene
    FAMILY
  • nanos family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localizes to the P-bodies, known centers of RNA degradation that are abundantly accumulated in male gonocytes (Suzuki 2010)
    basic FUNCTION
  • required for germ cell development (Suzuki 2007)
  • crucial factor in male germ cell development (Suzuki 2008)
  • involved in the maintenance of stem cells (Suzuki 2009)
  • plays an important role in both the maintenance and sexual development of germ cells (Suzuki 2010)
  • plays a key role during the sexual development of germ cells by suppressing meiosis and promoting male-type differentiation in the embryonic male gonads (Suzuki 2010)
  • plays a role in recruiting the CNOT4 deadenylation complex to trigger the degradation of specific RNAs (Suzuki 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CNOT4 (promotes the localization of CNOT4 and others CNOT proteins to P-bodies)( Suzuki 2010)
  • interacting with STRA8 (Suzuki 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS