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FLASH GENE

Symbol

NANOS2

contributors: mct/npt - updated : 02-09-2009

HGNC name	nanos homolog 2 (Drosophila)
HGNC id	23292

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.32      Physical location : 46.416.474 - 46.418.036
Synonym name	nanos homolog 2
Synonym symbol(s)	NOS2

DNA

TYPE	functioning gene
STRUCTURE	1.56 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001029861 1 - 1577 NP_001025032 - 138 - Kusz (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	in prenatal germ cells and at later stages in spermatogenesis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved zinc-finger domain

HOMOLOGY

Homologene

FAMILY

nanos family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	localizes to the P-bodies, known centers of RNA degradation that are abundantly accumulated in male gonocytes (Suzuki 2010)

basic FUNCTION	required for germ cell development (Suzuki 2007)
	crucial factor in male germ cell development (Suzuki 2008)
	involved in the maintenance of stem cells (Suzuki 2009)
	plays an important role in both the maintenance and sexual development of germ cells (Suzuki 2010)
	plays a key role during the sexual development of germ cells by suppressing meiosis and promoting male-type differentiation in the embryonic male gonads (Suzuki 2010)
	plays a role in recruiting the CNOT4 deadenylation complex to trigger the degradation of specific RNAs (Suzuki 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CNOT4 (promotes the localization of CNOT4 and others CNOT proteins to P-bodies)( Suzuki 2010)
	interacting with STRA8 (Suzuki 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS