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FLASH GENE
Symbol NANOS1 contributors: mct - updated : 24-08-2022
HGNC name nanos homolog 1 (Drosophila)
HGNC id 23044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one nanos-type zinc finger
    • HOMOLOGY
    Homologene
    FAMILY
  • nanos family
    • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    text concentrated in the perinuclear region
    basic FUNCTION
  • may regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3' untranslated
    • regions (UTRs) of mRNA targets
  • NANOS1, by regulating MMP14 expression, plays an important role in the acquisition of invasive properties by epithelial tumor cells
  • anti-apoptotic role of NANOS1 exerted by negative regulation of mRNAs of pro-apoptotic genes
  • NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with PUM2
  • SNAPIN interacts additionally with NANOS1 protein and the N-terminal region of NANOS1 is necessary for protein binding
  • NANOS1-PUM2 complex, together with DDX20 and small noncoding RNAs, possibly regulate mRNA translation within chromatoid body (CB) of the human germ cells
  • NANOS1 appears to contribute to the regulation of SIAH1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF12
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS