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FLASH GENE

Symbol

NANOS1

contributors: mct - updated : 24-08-2022

HGNC name	nanos homolog 1 (Drosophila)
HGNC id	23044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_199461 1 - 4627 NP_955631 - 292 - 2011 21800163

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Skeleton axial skeleton skull face maxilla

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatocyte Reproductive spermatogonia Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one nanos-type zinc finger

HOMOLOGY

Homologene

FAMILY

nanos family

CATEGORY

RNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope
text	concentrated in the perinuclear region

basic FUNCTION	may regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3' untranslated
	regions (UTRs) of mRNA targets
	NANOS1, by regulating MMP14 expression, plays an important role in the acquisition of invasive properties by epithelial tumor cells
	anti-apoptotic role of NANOS1 exerted by negative regulation of mRNAs of pro-apoptotic genes
	NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein	interacting with PUM2
	SNAPIN interacts additionally with NANOS1 protein and the N-terminal region of NANOS1 is necessary for protein binding
	NANOS1-PUM2 complex, together with DDX20 and small noncoding RNAs, possibly regulate mRNA translation within chromatoid body (CB) of the human germ cells
	NANOS1 appears to contribute to the regulation of SIAH1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF12

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS