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FLASH GENE
Symbol NANOS1 contributors: mct - updated : 24-08-2022
HGNC name nanos homolog 1 (Drosophila)
HGNC id 23044
Corresponding disease
SPGF12 spermatogenic failure 12
Location 10q26.11      Physical location : 120.789.227 - 120.793.854
Synonym name
  • nanos homolog 1
  • EC_Rep1a
    • Synonym symbol(s) NOS1, NOS-1, EC_Rep1a, SPGF12, ZC2HC12A
    DNA
    TYPE functioning gene
    STRUCTURE 4.63 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4627 - 292 - 2011 21800163
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Skeletonaxial skeletonskullfacemaxilla 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    Reproductivespermatogonia
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one nanos-type zinc finger
    • HOMOLOGY
    Homologene
    FAMILY
  • nanos family
    • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    text concentrated in the perinuclear region
    basic FUNCTION
  • may regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3' untranslated
    • regions (UTRs) of mRNA targets
  • NANOS1, by regulating MMP14 expression, plays an important role in the acquisition of invasive properties by epithelial tumor cells
  • anti-apoptotic role of NANOS1 exerted by negative regulation of mRNAs of pro-apoptotic genes
  • NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with PUM2
  • SNAPIN interacts additionally with NANOS1 protein and the N-terminal region of NANOS1 is necessary for protein binding
  • NANOS1-PUM2 complex, together with DDX20 and small noncoding RNAs, possibly regulate mRNA translation within chromatoid body (CB) of the human germ cells
  • NANOS1 appears to contribute to the regulation of SIAH1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF12
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS