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FLASH GENE
Symbol ENOSF1 contributors: mct - updated : 02-11-2022
HGNC name enolase superfamily member 1
HGNC id 30365
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines wide variety of cell lines,overexpressed in a 5-fluorocuro-cil-resistant cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • enolase superfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • having a catalytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TYMS differentially influencing cell sensibility to TYMS inhibitors
  • ENOSF1 modify TYMS expression at the RNA level by acting as an antisense molecule to TYMS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    digenic germline variants in both TYMS and ENOSF1 can generate disease features of dyskeratosis congenita
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • peptide regions of SERPINA1 and ENOSF1 expression are potential serum biomarkers for gastric cancer
    • Therapy target
    ANIMAL & CELL MODELS