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FLASH GENE

Symbol

ENOSF1

contributors: mct - updated : 02-11-2022

HGNC name	enolase superfamily member 1
HGNC id	30365

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	overlapping, gene in gene, opposite orientation
text	ENOSF1 partially overlaps TYMS on chromosome 18 and is transcribed in the opposite direction to TYMS
STRUCTURE	49.65 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map

see TYMS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017512 16 - 5362 NP_059982 49 443 - 2005 16162288 NM_202758 15 - 5464 NP_974487 - 477 - 2005 16162288 NM_001318760 14 - 5364 NP_001305689 - 262 - 2005 16162288 NM_001354065 15 - 5246 NP_001340994 - 361 - 2005 16162288 NM_001354066 15 - 5320 NP_001340995 - 429 - 2005 16162288 NM_001354067 16 - 5506 NP_001340996 - 491 - 2005 16162288 NM_001354068 13 - 5275 NP_001340997 - 414 - 2005 16162288

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	wide variety of cell lines,overexpressed in a 5-fluorocuro-cil-resistant cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

enolase superfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION

having a catalytic activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to TYMS differentially influencing cell sensibility to TYMS inhibitors
	ENOSF1 modify TYMS expression at the RNA level by acting as an antisense molecule to TYMS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       digenic germline variants in both TYMS and ENOSF1 can generate disease features of dyskeratosis congenita

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	peptide regions of SERPINA1 and ENOSF1 expression are potential serum biomarkers for gastric cancer
Therapy target

ANIMAL & CELL MODELS