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FLASH GENE
Symbol PLPPR4 contributors: mct - updated : 07-09-2020
Location 1p21.3      Physical location : -
Genatlas name lipid phosphate phosphatase-related protein type 4
Synonym name
  • plasticity related gene 1
  • brain-specific phosphatidic acid phosphatase-like protein 1
  • Synonym symbol(s) PHP1, PRG1, KIAA0455, PRG-1, RP4-788L13.1, hCG_2039366, LPR4, LPPR4
    EC.number 3.1.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 45.30 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5040 82 763 - 2003 12730698
    6 - 4867 - 705 - 2003 12730698
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Endocrineadrenal gland    
     neuroendocrinepituitary   
    Nervousbrain   specific
     brainlimbic system    Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
     brainhindbraincerebellumcerebellar cortex  Homo sapiens
    Reproductivemale systemtestis  lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six N-terminal
  • membrane-spanning regions with highly conserved phosphatase domains
  • a long hydrophilic domain of approximately 400 AAs, which appears to be located on the cytoplasmic side and may be having a role as a regulatory or signal transduction domain
  • C-terminal putative cytoplasmic domain (AAs 466-766) binds equimolar amounts of CALM1 in a Ca2+-dependent manner, with a relatively high affinity
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • PA-phosphatase related phosphoesterase family
  • PLPPR family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • in the membranes of outgrowing axons
  • localizes at the postsynaptic compartment of excitatory synapses and dendritic shafts of hippocampal neurons, but is not present in presynaptic nerve terminals
  • basic FUNCTION
  • facilitating axonal outgrowth during development and regenerative sprouting
  • may modulate excitatory transmission via lipid phosphate-mediated signaling
  • modulates excitation at the synaptic junction
  • important molecule in the control of hippocampal excitability dependent on presynaptic LPA2 receptor signaling
  • may be involved in postsynaptic functions regulated by intracellular Ca2+-signalling
  • protects neuronal cells from lysophosphatidic acid (LPA) effects
  • protective role in the vascular media under pathophysiological conditions
  • may act by modifying bioactive lipids and their signaling pathways, rather than possessing an ecto-phosphatase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NEUROD6 directly regulates LPPR4 expression and the NEUROD6 -LPPR4 cascade plays an important role in neurite outgrowth
  • neuronal calmodulin-binding protein
  • new functional cooperation between PLPPR family members and discovered for the first time that PLPPRs likely exert their function through forming complex with its family members
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may serve as a new therapeutic target for patients with GC peritoneal metastasis
    ANIMAL & CELL MODELS
  • deletion of Prg-1 in mice leads to epileptic seizures and augmentation of excitatory postsynaptic current (EPSC) but not inhibitory postsynaptic current (IPSC)