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FLASH GENE
Symbol TFG contributors: mct - updated : 03-01-2019
HGNC name TRK-fused gene
HGNC id 11758
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal coiled-coil region homolog to the N terminus of EWS and FUS, coiled-coil domain responsible for TRK-T3 oligomerization ; and has been previously identified in chromosome translocation events involving two protein kinases, which created a pair of oncogenes
  • one SPYGQ-rich region
  • octicosapeptide repeats
    • HOMOLOGY
    interspecies homolog to murine Tfg
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localized at endoplasmic reticulum (ER) exit sites
    • basic FUNCTION
  • able to modulate PTPN6 activity
  • enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity
  • target of chromosome translocations in lymphoma and soft tissue tumors, fused to GPR128 in healthy individuals
  • is localized in the cytoplasm, and likely modulates alternative splicing indirectly
  • putative metastatic melanoma tumor suppressor gene
  • TFG plays a pivotal role in negative regulation of RNA-sensing, DDX58-like receptor (RLR) family signaling pathways
  • proline/glutamine-rich domain in TFG was critical for regulation of the ubiquitin-proteasome system (UPS) and proper localization at ER exit sites
  • TFG functions at the ER/ERGIC interface to locally concentrate COPII-coated transport carriers and link exit sites on the ER to ERGIC membranes
  • is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER
  • reported to be involved in the regulation of cell size, apoptosis, cell growth, ER-Golgi protein secretion, NFKB1 pathway signaling, the ubiquitin-proteasome system, and pancreatic beta-cell mass and function
  • key role for TFG-mediated protein transport in the pathogenesis of hereditary spastic paraplegia (HSP)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    potential novel member of the NF-kappaB pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates and regulates the activity of the tyrosine phosphatase PTPN6
  • regulator of protein secretion that interacts directly with SEC16A
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • HNRNPH1 and TFG modulate the splicing activity of RBFOX1/2, whereas RALY had no effect
  • TFG plays likely a pivotal role in negative regulation of RNA-sensing, DDX58 family signaling pathways
  • TFG is an inhibitory regulator of the UPS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMSNP , SPG57
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma
    ANIMAL & CELL MODELS